图像
伊恩·孟

伊恩·D. 孟,Ph值.D.

教授,生理

Director, Center of Biomedical 研究 Excellence for the Study of 疼痛 and Sensory Function

位置

斯特拉·马里斯大厅203
在校园
合资格申请学生机会

Dr. 伊恩·孟 received his ScB and PhD in 神经科学 at 布朗大学.  Following completion of his PhD, he worked as a postdoctoral fellow with Dr. Howard Fields in the Department of Neurology at the University of California, 旧金山分校, studying the brain circuits mediating the analgesic properties of cannabinoids.  Dr. Meng joined the 365速发国际网站 (365速发国际) in 2003 where he is currently a professor of Biomedical 科学s, Director of the Center for Excellence in the 神经科学s (CEN), and the Director of the National Institute of 健康 (NIH) funded Center for the Study of 疼痛 and Sensory Function.  在一个, he has maintained a continuously funded research program with the aim of understanding trigeminal sensory processing underlying headache and ocular 疼痛 and homeostasis, with an emphasis on two conditions: headache and dry eye.   Dr. Meng's lab is currently investigating sensory neurons that regulate tearing and ocular 疼痛 under both normal and pathological conditions such as dry eye.  Additional projects are exploring the ability of corneal afferents to promote corneal heaing by providing trophic support to the injured cornea in dry eye.   

凭证

教育

Sc.B.
布朗大学
1991
Ph.D.
布朗大学
1997

博士后训练

博士后训练, Department of Neurology
University of California, San Francisco (San Francisco, California)

研究

目前的研究

博士的首要目标是. Meng's research is to understand trigeminal sensory processing underlying headache and ocular 疼痛 and homeostasis, with an emphasis on two conditions: medication overuse headache and dry eye syndrome. Dr. Meng's lab is currently investigating sensory neurons that regulate tearing and ocular 疼痛 under both normal and pathological conditions such as dry eye. 在与头痛相关的研究中,Dr. Meng's research aims to understand the neuroplastic changes induced by the chronic use of analgesics, as such treatments have been shown to transform episodic migraines into chronic daily headache. 

选定的出版物

1. Hitomi S, Kross K, Kurose M, Porreca F, Meng ID. Activation of dura-sensitive trigeminal neurons and increased c-Fos protein induced by morphine withdrawal in the rostral ventromedial medulla. 头痛. 2016年5月6日. pii: 0333102416648655.[Epub ahead of print] PubMed PMID: 27155000.
2. Harasawa I, Johansen JP, Fields HL, Porreca F, Meng ID. Alterations in the rostral ventromedial medulla after the selective ablation of μ-opioid receptor expressing neurons. 疼痛. 2016年1月,157 (1):166 - 73. doi: 10.1097/j.疼痛.0000000000000344. PubMed PMID: 26335909; PubMed Central PMCID: PMC4829402.
3. 孟ID, Barton ST, Mecum NE, Kurose M. Corneal sensitivity following lacrimal gland excision in the rat. 投资眼科科学. 2015年5月,56 (5):3347 - 54. doi: 10.1167 / iovs.15-16717. PubMed PMID: 26024120; PubMed Central PMCID: PMC4453983.
4. 孟ID, Kurose M. The role of corneal afferent neurons in regulating tears under normal and dry eye conditions. Exp眼睛Res. 2013年12月,117:79 - 87. doi: 10.1016/j.前女友.2013.08.011. 审查. PubMed PMID: 23994439; PubMed Central PMCID: PMC3989072.
5. 库罗斯M,孟身份. Dry eye modifies the thermal and menthol responses in rat corneal primary afferent cool cells. J Neurophysiol. 2013年7月,110 (2):495 - 504. doi: 10.1152/jn.00222.2013. PubMed PMID: 23636717; PubMed Central PMCID: PMC3727064.
6. Robbins A, Schmitt D, Winterson BJ, Meng ID. 增加慢性吗啡
Fos-positive neurons after concurrent cornea and tail stimulation. 头疼. 2012年2月,52 (2):262 - 73. doi: 10.1111/j.1526-4610.2011.01999.x. PubMed PMID: 21929659;PubMed Central PMCID: PMC3244550.
7. Reynolds J, Bilsky EJ,孟ID. Selective ablation of mu-opioid receptor expressing neurons in the rostral ventromedial medulla attenuates stress-induced mechanical hypersensitivity. 生命科学. 2011年8月29日,89 (9):313 - 9. doi: 10.1016/j.lfs.2011.06.024. PubMed PMID: 21763327.
8. Meng ID, Dodick D, Ossipov MH, Porreca F. Pathophysiology of medication overuse headache: insights and hypotheses from preclinical studies. 头痛. 2011年5月,31 (7):851 - 60. doi: 10.1177/0333102411402367. 审查. PubMed PMID: 21444643.
9. 库罗斯M,孟身份. Corneal dry-responsive neurons in the spinal trigeminal nucleus respond to innocuous cooling in the rat. J Neurophysiol. 2013年5月,109(10):2517 - 22所示. doi: 10.1152/jn.00889.2012. PubMed PMID: 23446686; PubMed Central PMCID: PMC3653041.
10. Robbins A, Kurose M, Winterson BJ, Meng ID. Menthol activation of corneal cool cells induces TRPM8-mediated lacrimation but not nociceptive responses in rodents. 投资眼科科学. 2012年10月9日,53 (11):7034 - 42. doi: 10.1167 / iovs.12-10025. PubMed PMID: 22952122; PubMed Central PMCID: PMC3471555.

研究兴趣

Ocular 疼痛; dry eye; migraine headache; medication overuse headache; transformation of migraine headache to chronic daily headache.

研究主题

动物模型
神经科学与疼痛
神经科学
疼痛
感觉神经元
转基因小鼠

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